Others Parasite In City

Parasite In City is a PIXEL FACTORY side-scrolling indie survival-horror Japanese game built on pixel graphics. The city has become a breeding ground of horror; the protagonist has to help the blonde escape.

The dev openly states the meta-pitch: this is the game a hell of a lot of developers now copy, so you know it's fun. The 2DCG pixel art carries the cast across the side-scroller combat / escape loop. Content threads pregnancy outcomes, female protagonist core, animated scenes, censored visuals where the license requires, combat-driven encounters, dystopian setting, group sex, horror core register, internal-view, lesbian routes, male-domination beats, masturbation, monster encounters, multiple-penetration, oral, animated rape content, spanking, tentacles, voiced lines, vore content, and the wide adult tag stack the infected city supports.

A foundational pixel side-scroller in the niche, widely emulated for a reason.